Yes, but it's extremely rare. Only a few mods affect your save file at all. If you avoid those, mods are very unlikely to corrupt your save file. If you're worried, just back up [[#Save files|your save files]] occasionally. That's strongly recommended even if you don't use mods, since save corruption is almost always caused by the game itself.
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Yes, but it's extremely rare. Only a few mods affect your save file at all. If you avoid those, mods are very unlikely to corrupt your save file. In most cases, you can fix save corruption by [[Saves#Undo the last save|undoing the last save]].
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In most cases, you can fix save corruption by [[Saves#Undo the last save|undoing the last save]].
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If you're worried, just back up [[#Save files|your save files]] occasionally. That's strongly recommended even if you don't use mods, since save corruption is almost always caused by the game itself. SMAPI also creates a daily backup of your saves automatically; you can retrieve those from the <tt>Mods/SaveBackup</tt> folder.
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{{SMAPI upcoming|2.6 beta|content=SMAPI comes with a Save Backup mod by default. This creates daily backups of your save files in the <tt>Mods/SaveBackup</tt> folder.}}