All hotkeys can be reassigned by opening the menu and choosing the Options tab Optionstab.png

Keyboard & Mouse

Key Description
W A S D W moves the character up, A moves left, S moves down, D moves right
Left Click, C Use tool
Right Click, X Check/Do Action
Escape, E Open Menu
F Open Journal
M Open Map window
Left Shift Run
1-0, -, + Inventory hotkeys
F4 Screenshot mode
Mouse Selection: You can also click on any item position with your mouse, even empty ones (which cannot be done with the mouse wheel or even the hotkeys).

Xbox One / Xbox 360 Controller

Controller buttons can not be reassigned.

In Overworld

Button Description
 
Left Joystick
Walk; Run
 
POV
Walk
 
Right Joystick
Move Cursor
 
Start
Open Menu
 
Back
Open Journal
 A Check / Do Action / Use Cursor
 X Use Tool
 B Open Menu
 Y Open Crafting Menu
 LT  RT Switch Item

In Menu

Button Description
Left Joystick Move Cursor
Right Joystick Scroll
A Select
B, Y, Start Exit Menu
LT, RT Switch Menu Tab
X Move One Item / Use Item (bait, etc.)